一、基本情况
姓 名：郭 睿
性 别：男
政治面貌：中共党员
职 称：副教授，博士生导师
职 务：福建农林大学蜂学与生物医药学院中心实验室主任、纪检委员、蜂学系副主任兼共青团委副书记，天然生物毒素国家地方联合工程实验室副主任，蜂疗研究所副所长
研究方向：宿主—病原互作，昆虫及其病原非编码RNA、转基因及前沿组学，蜜蜂疾病诊疗与防控技术开发及应用，蜂毒肽抗肿瘤与抗炎症，新型诊断标志物和治疗靶点开发，精准医学
联系电话：15205080780
电子邮箱：fafu_ruiguo@126.com, ruiguo@fafu.edu.cn
二、个人简介
郭睿，副教授，博士生导师，国家自然科学基金函评专家，中国知网最具影响力学者、高被引学者Top1%、高被引学者，福建农林大学“百人攀登”计划培育对象、杰出青年科研人才、A类博士引进人才、硕士生导师团队带头人；兼任福建省养蜂学会副秘书长、理事，福建省省级科技特派员、科特派团队负责人；曾获校代表性科研成果与重大社会服务贡献奖二等奖、院科研成果与社会服务贡献奖一等奖（3次）和二等奖及博士研究生国家奖学金等奖励；荣获福建农林大学优秀党员、优秀教师、优秀班主任、青年五四奖章集体和青年五四奖章个人（3次）等荣誉；主讲研究生课程《蜂学专业英语》和本科生课程《蜂学专业英语》，参讲研究生课程《分子生物学与基因工程》；主持福建农林大学硕士生导师团队项目、研究生教育教学研究项目和本科生重点教改项目；主持国家自然科学基金面上项目、青年项目，福建省自然科学基金面上项目、青年创新项目，福建省教育厅中青年教师教育科研项目，福建农林大学杰出青年科研人才项目等国家级、省部级、市厅级和校级科研项目20余项；作为核心成员参与国家自然科学基金面上项目、国家现代农业蜂产业技术体系项目和福建省自然科学基金面上项目等；以通讯作者或第一作者身份在Antioxidants、Biology、Frontiers in Immunology、Applied Microbiology and Biotechnology、International Journal of Molecular Sciences、Frontiers in Microbiology、Current Microbiology、Frontiers in Cell and Developmental Biology、Apidologie、Frontiers in Physiology、Journal of Invertebrate Pathology、 Frontiers in Genetics、Journal of Apicultural Research、Insects、Parasitology Research、Gene、Genes、《生物工程学报》、《微生物学报》、《菌物学报》、《中国农业科学》和《昆虫学报》等国内外高质量刊物上发表学术论文200余篇（含SCI期刊论文50余篇）；11篇和23篇学术论文分获世界养蜂大会口头报告和学术海报资格；27篇论文获亚洲养蜂大会口头报告资格；1篇论文入选中国精品科技期刊顶尖学术论文（F5000）；33篇论文获评中国知网学术精要高影响力论文；1篇论文荣获《微生物学报》2021年度优秀论文；1篇论文荣获《菌物学报》2024年度优秀论文；29篇论文入选中国畜牧科技论坛论文集；18篇论文入选中国昆虫学会学术年会论文集；14篇论文入选中国菌物学会2023年学术年会论文集；获授权发明专利3项、新型实用专利3项；受邀担任国际蜂学领域专业期刊Frontiers in Bee Science和SCI期刊Biomolecules审稿编委，Veterinary Sciences、Frontiers in Physiology、Life、Genes、Frontiers in Genetics等SCI期刊的客座编委，中文核心期刊《环境昆虫学报》蜜蜂研究栏目特邀编委和《安徽农业大学学报》首届青年编委，Journal of Hazardous Material、International Journal of Biological Macromolecules、RNA Biology、《微生物学报》、《畜牧兽医学报》和《昆虫学报》等50余本国内外学术期刊的审稿专家；指导在读博士生2人、硕士生32人，指导2名博士生和8名硕士生获研究生国家奖学金，3名硕士生获福建农林大学优秀硕士学位论文资助基金立项资助，多篇论文获校优秀硕士学位论文；指导在读本科生60余人，作为第一作者发表权威及核心期刊论文10余篇，指导本科生6人获国家奖学金，7人推免至985和211大学攻读硕士学位，多人获校优秀毕业论文，多人获国家级、省级和校级大学生创新创业训练计划项目立项资助，多个作品获“挑战杯”竞赛省赛三等奖、校赛一等奖和院赛一等奖。
学术任职：
（1）福建省养蜂学会副秘书长、理事，2023-至今
（2）Frontiers in Bee Science审稿编委，2022-至今
（3）Biomolecules审稿编委，2023-至今
（4）《环境昆虫学报》蜜蜂研究栏目特邀编委，2024-至今
（5）《安徽农业大学学报》首届青年编委，2024-至今
（6）Veterinary Science客座编委，2022-2023
（7）Frontiers in Genetics客座编委，2024-至今
（8）Life客座编委，2022-2023
（9）Genes客座编委，2024-至今
（10）Frontiers in Physiology客座编委，2022-2023
（11）Frontiers in Genetics客座编委，2022-2023
（12）Journal of Hazardous Materials、International Journal of Biological Macromolecules、RNA Biology、Microbiological Spectrum、Frontiers in Microbiology、Frontiers in Physiology、Frontiers in Bee Science、Frontiers in Genetics、Parasitology Research、Journal of Invertebrate Pathology、Ecotoxicology and Environmental Safety、Progress in Biophysics and Molecular Biology、Journal of Asia-Pacific Entomology、Microorganisms和Pathogens等40余本SCI期刊的审稿专家
（13）《微生物学报》、《畜牧兽医学报》、《昆虫学报》和《环境昆虫学报》等10余本中文核心期刊的审稿专家
学术报告：
（1）Overexpression and knockdown of ace-miR-3720 impacts target gene expression and weight of Apis cerana cerana larval gut. 第47届世界养蜂大会, 口头报告, 土耳其伊斯坦布尔, 2022-8-24至2022-8-28
（2）Regulatory network and putative function of long non-coding RNAs in Nosema ceranae spore. 第47届世界养蜂大会, 口头报告, 土耳其伊斯坦布尔, 2022-8-24至2022-8-28
（3）Uncovering the new world of non-coding RNAs in two widespread fungal pathogens of honeybee. 第46届世界养蜂大会, 学术海报, 加拿大蒙特利尔, 2019-9-8至2019-9-12
（4）De novo transcriptome assembly of Apis cerana cerana larval gut and identification of immune responses to Ascosphaera apis infection. 第45届世界养蜂大会, 口头报告, 土耳其伊斯坦布尔, 2017-9-29至2017-10-4
（5）Regulatory role and molecular mechanism of circRNA in response of Apis cerana cerana larvae to Ascosphaera apis invasion. 国际蜂联亚洲区域学术研讨会, 口头报告, 中国北京, 2024-09-02至2024-09-04
（6）Genome-wide identification of circular RNAs in eastern honeybee. 第二届蜜蜂与健康国际学术研讨会, 口头报告, 中国福州, 2019-05-28至2019-05-29
专 利：
（1）一种纤维强化巢础及其制造方法. (已授权, 专利号: ZL201810295779.2)
（2）一种转基因家蚕微孢子虫连续感染系的构建方法. (已授权, 专利号: 201210242668.8)
（3）一种家蚕质型多角体病毒的体外构建方法. (已授权, 专利号: 201510209183.2)
（4）一种表达红色荧光蛋白的重组家蚕质型多角体病毒的构建方法. (已授权, 专利号: 201510209184.7)
（5）可溯源辐射式摇蜜机. (已授权, 专利号: 201720351002.4)
（6）可溯源弦式摇蜜机. (已授权, 专利号: 201720350997.2)
社会服务：
（1）国家现代农业蜂产业技术体系岗位科学家团队，核心成员
（2）福建省科技特派员团队，负责人，2021
（3）福建省科技特派员，个人，2021
（4）福建省科技特派员，个人，2022
（5）福建省科技特派员，个人，2023
荣誉奖励：
（1）中国知网最具影响力学者，2024
（2）中国知网高被引学者Top1%，2024
（3）中国知网高被引学者，2024
（4）福建农林大学代表性科研成果与重大社会服务贡献奖申报书（科研育人突出业绩奖），2020，排名第二
（5）福建农林大学蜂学与生物医药学院科研成果与社会服务贡献奖二等奖，2024，排名第一
（6）福建农林大学动物科学学院（蜂学学院）科研成果与社会服务贡献奖一等奖，2023，排名第一
（7）福建农林大学动物科学学院（蜂学学院）科研成果与社会服务贡献奖一等奖，2020，排名第二
（8）福建农林大学动物科学学院（蜂学学院）科研成果与社会服务贡献奖一等奖，2022，排名第二
（9）福建农林大学动物科学学院（蜂学学院）科研成果与社会服务贡献奖二等奖，2021，排名第二
（10）福建农林大学首届“百人攀登”计划培育对象，2023
（11）福建农林大学杰出青年科研人才，2017
（12）福建农林大学A类博士引进人才，2015
（13）福建农林大学优秀教师，2020
（14）福建农林大学优秀班主任，2020
（15）福建农林大学青年五四奖章（集体），2022
（16）福建农林大学青年五四奖章（个人），2024
（17）福建农林大学青年五四奖章（个人），2018
（18）福建农林大学青年五四奖章（个人），2017
（19）5篇论文获评中国精品科技期刊顶尖学术论文（F5000），2022-2024
（20）1篇论文获评《微生物学报》年度优秀论文，2021
（21）1篇论文获评《菌物学报》年度优秀论文，2024
（22）33篇论文获评中国知网《学术精要库》高影响力论文，2022-2023
（23）福建农林大学动物科学学院（蜂学学院）神蜂科技奖教金，2023
（24）福建农林大学动物科学学院（蜂学学院）大北农奖教金，2022
（25）苏州大学博士研究生国家奖学金，2013
（26）苏州大学博士研究生学业一等奖学金，2012
三、受教育经历
2012.9-2015.6 苏州大学，基础医学与生物科学学院，博士研究生
2009.9-2012.7 苏州大学，基础医学与生物科学学院，硕士研究生
2005.9-2009.7 淮北师范大学，生命科学学院，本科生
三、研究工作经历
2024.1-至今，福建农林大学，蜂学与生物医药学院，副教授
2023.6-2023.12，福建农林大学，动物科学学院（蜂学学院），副教授
2019.9-2023.5，福建农林大学，动物科学学院（蜂学学院），讲师
2015.8-2019.8，福建农林大学，蜂学学院，讲师
四、科研项目
（1）国家自然科学基金面上项目(32372943) ，50万，主持，2024-2028，在研
（2）国家自然科学基金青年基金项目(31702190)，22万，主持，2017-2020，已结题
（3）国家现代农业产业体系（蜜蜂）建设专项资金(CARS-44-KYJ7)，350万，参与，核心成员，2016-2020，在研
（4）国家现代农业产业体系（蜜蜂）建设专项资金(CARS-44-KYJ7)，300万，参与，核心成员，2021-2025，已结题
（5）福建省自然科学基金面上项目（2022J01131334），7万，主持，2022-2025，在研
（6）福建省自然科学基金青年创新项目(2018J05042)，4万，主持，2018-2020，已结题
（7）福建省教育厅中青年教师教育科研项目(JAT170158)，2万，主持，2017-2020，已结题
（8）福建农林大学“百人攀登”计划（郭睿），15万，主持，2023，在研
（9）福建农林大学杰出青年学者科研人才项目(xjq201814)，30万，主持，2019-2022，已结题
（10）福建农林大学科技创新专项基金(KFb22060XA)，17.8万，主持，2022-2024，在研
（11）福建农林大学科技创新专项基金(CXZX2017342)，22万，主持，2017-2019，已结题
（12）农业部授粉昆虫生物学重点实验室开放基金(2017MFNZS02)，5万，主持，2017-2019，已结题
（13）江西省蜜蜂生物学与饲养重点实验室开放基金项目（JXKLHBB-2020-04），2万，主持，2020 ，已结题
（14）福建省病原真菌与真菌毒素重点实验室开放课题（郭睿），2万，主持，2020 ，在研
（15）福建农林大学A类博士科研启动经费，5万，主持，2015-2017，已结题
（16）福建农林大学动物科学学院（蜂学学院）科研扶持项目（郭睿），5万，主持，2022-2023，已结题
五、承担课程
（1）本科生《蜂学专业英语》（主讲）
（2）本科生《蜜蜂保护学》（参讲）
（3）研究生《蜂学专业英语》（主讲）
（4）研究生《蜜蜂研究进展》（参讲）
（5）研究生《分子生物学与基因工程》（参讲）
六、科研成果
（1）在分子水平揭示蜂毒肽抗肝癌、乳腺癌和宫颈癌的作用机制；
（2）系统鉴定西方蜜蜂、东方蜜蜂、东方蜜蜂微孢子虫和蜜蜂球囊菌的miRNA、lncRNA和circRNA；
（3）成功建立西方蜜蜂、东方蜜蜂、东方蜜蜂微孢子虫和蜜蜂球囊菌基因、miRNA、lncRNA和circRNA的功能研究技术体系；
（4）全面解析ncRNA调控蜜蜂—东方蜜蜂微孢子虫、蜜蜂幼虫—蜜蜂球囊菌互作的功能及作用机制；
（5）全面解析ncRNA调控西方蜜蜂和东方蜜蜂肠道发育的分子机理；
（6）组装和注释东方蜜蜂微孢子虫和蜜蜂球囊菌的首个染色体级别基因组；
（7）构建和注释西方蜜蜂、东方蜜蜂、东方蜜蜂微孢子虫和蜜蜂球囊菌的首个高质量全长转录组，并解析基因的可变剪接与可变多聚腺苷酸化；
（8）鉴定和开发出蜜蜂微孢子虫病、蜜蜂白垩病诊疗的系列新型生物标志物和分子靶点。
七、代表性论文与著作
代表性论文（作为通讯作者或第一作者）
2025年
[1] Yuxuan Song#, Jianfeng Qiu#, Jing Kang, Ying Chen, Ruihua Cao, Wei Wang, Mengyuan Dai, Dafu Chen, Zhongmin Fu, Rui Guo*. Transcriptomic characterization of miRNAs in Apis cerana larvae responding to Ascosphaera apis infection. Genes, 2025, 16(2): 156.
[2] 李坤泽#, 杜丽婷#, 王梦怡, 胡艳雯, 吴函雨, 严提珍, 邱剑丰, 卢兆辉, 陈大福, 骆庆明*, 郭睿*. 中华蜜蜂幼虫肠道体液免疫通路相关基因及其剪接体鉴定. 昆虫学报, 2025, 知网首发.
[3] 张艺琼#, 李琪明#, 董舒楠, 王宁, 康婧, 宓诗雨, 吴鹰, 蒋海宾, 陈大福*, 郭睿*. 意大利蜜蜂piR-ame-1128833的靶mRNA和功能分析, 昆虫学报, 2025, 知网首发.
[4] 刘治滩#, 叶道有#, 宓诗雨, 王宁, 郑一荻, 蒋海宾, 吴鹰, 徐细建, 陈大福, 邱剑丰*, 郭睿*. 东方蜜蜂MMP14基因的表达模式与蛋白分子特征. 昆虫学报, 2025, 知网首发.
[5] 张艺琼#, 那志豪, 李琪明, 王梦怡, 李婧娴, 代梦远, 邱剑丰, 张荣华, 卢兆辉, 陈大福. 严提珍*, 郭睿*. 意大利蜜蜂piR-ame-1186994的靶基因与功能分析, 昆虫学报, 2025, 知网首发.
[6] 宋宇轩#, 李坤泽#, 臧贺, 刘小玉, 吴陶, 徐细建, 刘锋, 骆群, 邱剑丰, 陈大福*, 郭睿*. 意大利蜜蜂lncRNA1583的调控作用和表达模式分析.昆虫学报, 2025, 已录用.
[7] 冯佩林#, 朱乐冉#, 臧贺, 刘小玉, 康婧, 邱剑丰, 刘锋, 徐细建, 骆群, 陈大福, 郭睿*, 徐国钧*. 西方蜜蜂肽聚糖识别蛋白相关基因的剪接体鉴定及分析. 昆虫学报, 2025, 已录用.
[8] 董舒楠#, 曹瑞华#, 荆欣, 臧贺, 陈颖, 孙恺玥, 刘锋, 徐细建, 骆群, 陈大福,邱剑丰*, 郭睿*. 西方蜜蜂lncRNA13922的时空表达谱与调控作用. 昆虫学报, 2025, 已录用.
[9] 郭思佳#, 刘小玉#, 王梦怡, 臧贺, 范小雪, 吴陶, 张天泽, 严提珍, 骆庆明, 陈大福, 邱剑丰*, 郭睿*. 东方蜜蜂DNA甲基转移酶3的分子特征、系统进化和基因表达模式. 昆虫学报, 2025, 已录用.
[10] 陈颖#, 康婧#, 臧贺, 王勇杰, 张凯遥, 叶道有, 冯睿蓉, 陈大福, 徐国钧, 郭睿*, 邱剑丰*. 中华蜜蜂14-3-3ζ基因的分子克隆、表达模式及蛋白分子特征. 昆虫学报, 2025, 已录用.
[11] 杜丽婷#, 王梦怡#, 樊念, 吴陶, 张荣华, 谢润桂, 严提珍, 付中民, 陈大福*, 郭睿*, 邱剑丰*. 东方蜜蜂死亡捕手蛋白的分子特征及基因表达模式. 环境昆虫学报, 2025, 知网首发.
[12] 宋宇轩#, 张荣华#, 董舒楠, 王梦怡, 范小雪, 李婧娴, 宓诗雨, 王美仪, 邱剑丰, 陈大福, 严提珍*, 郭睿*. 意大利蜜蜂体液免疫通路相关基因及其剪接分析. 环境昆虫学报, 2025, 已录用.
[13] 范小雪#, 叶亚萍#, 张佳欣, 高旭泽, 张艺琼, 姚雨彤, 毛予立, 牛庆生, 陈大福,付中民*, 郭睿*. 意大利蜜蜂MAPK信号通路相关基因和全长转录本鉴定及分析. 应用昆虫学报, 2025, 已录用.
2024年
[1] Xiaoxue Fan#, Haodong Zhao#, He Zang#, Shunan Dong, Jianfeng Qiu, Yuxuan Song, Kunze Li, Haibin Jiang, Ying Wu, Yang Lü, Dingding Zhou, Zhongmin Fu, Dafu Chen, Rui Guo*. Extensive influence of microsporidian infection on sucrose solution consumption, antioxidant enzyme activity, cell structure, and lifespan of Asian honeybees. Frontiers in Immunology, 2024, 15: 1404766
[2]Rui Guo#, Kaiyao Zhang#, He Zang, Sijia Guo, Xiaoyu Liu, Xin Jing, Yuxuan Song, Kunze Li, Ying Wu, Haibing Jiang, Zhongmin Fu, Dafu Chen*. Dynamics and regulatory role of circRNAs in Asian honey bee larvae following fungal infection. Applied Microbiology and Biotechnology, 2024, 108: 261.
[3] Xiaoxue Fan#, Xuze Gao#, He Zang, Zhitan Liu, Xin Jing, Xiaoyu Liu, Sijia Guo, Haibing Jiang, Ying Wu, Zhijian Huang, Dafu Chen, Rui Guo*. Transcriptional dynamics and regulatory role of miRNAs in Ascosphaera apis invading western honey bee (Apis mellifera) larvae. Frontiers in Microbiology, 2024, 15: 1355035.
[4] Xuze Gao#, He Zang#, Xiaoyu Liu, Sijia Guo, Daoyou Ye, Zhitan Liu, Xin Jing, Qingsheng Niu, Ying Wu, Yang Lü, Dafu Chen, Rui Guo*. Unraveling the modulatory manner and function of circRNAs in the Asian honey bee larval guts. Frontiers in Cell and Developmental Biology, 2024, 12: 13917107.
[5] Shunan Dong#, Kunze Li#, He Zang, Yuxuan Song, Jing Kang, Ying Chen, Liting Du, Ning Wang, Dafu Chen, Qingming Luo, Tizhen Yan*, Rui Guo*, Jianfeng Qiu*. ame-miR-5119-Eth axis modulates larval-pupal transition of western honeybee worker. Frontiers in Physiology, 2024, 15: 1475306.
[6] He Zang#, Sijia Guo#, Shunan Dong, Yuxuan Song, Kunze Li, Xiaoxue Fan, Jianfeng Qiu, Yidi Zheng, Haibin Jiang, Ying Wu, Yang Lü, Dafu Chen, Rui Guo*. Construction of a full-length transcriptome of western honeybee midgut tissue and improved genome annotation. Genes, 2024, 15: 728.
[7] Sijia Guo#, He Zang#, Xiaoyu Liu, Xin Jing, Zhitan Liu, Wende Zhang, Mengyi Wang, Yidi Zheng, Zhengyuan Li, Jianfeng Qiu, Dafu Chen, Tizhen Yan*, Rui Guo*. Full-length transcriptome construction and systematic characterization of virulence factor-associated isoforms in Vairimorpha (Nosema) ceranae. Genes, 2014, 15: 111.
[8] 叶亚萍#, 刘治滩#, 李琪明, 臧贺, 冯佩林, 王宁, 王杰, 黄枳腱, 陈大福*, 郭睿*. 西方蜜蜂AmAGO1蛋白的分子特性、时空表达谱及抗体制备. 昆虫学报, 2024, 67(1): 18-28.
[9] 宋宇轩#, 李坤泽#, 荆欣, 范小雪, 臧贺, 邹培缘, 陈大福, 付中民*, 郭睿*. 中华蜜蜂全长转录组构建与注释. 昆虫学报, 2024, 67(2): 183-192.
[10] 李坤泽#, 宋宇轩#, 臧贺, 荆欣, 范小雪, 陈颖, 那志豪, 陈大福, 付中民*, 郭睿*. 利用纳米孔长读段数据完善东方蜜蜂参考基因组序列和功能注释. 昆虫学报, 2024, 67(3): 346-357.
[11] 赵浩东#, 臧贺#, 叶道有, 陈颖, 王宁, 吴鹰, 蒋海宾, 冯睿蓉, 陈大福, 熊翠玲*, 郭睿*. 意大利蜜蜂幼虫肠道发育过程中lncRNA的表达谱和调控作用. 昆虫学报, 2024, 67(8): 1050-1062.
[12] 李坤泽#, 宋宇轩#, 李婧娴, 臧贺, 冯佩林, 刘小玉, 冯睿蓉, 刘彩珍, 陈大福,付中民*, 郭睿*. 意大利蜜蜂lncRNA16999的调控作用分析和表达谱测定. 昆虫学报, 2024, 已录用.
[20] 邹培缘#, 臧贺#, 董舒楠, 叶道有, 杜丽婷, 邱剑丰, 付中民, 陈大福*, 郭睿*. 西方蜜蜂CKI1蛋白的分子特征和基因时空表达谱. 环境昆虫学报, 2024, 已录用.
[22] 宋宇轩#, 董舒楠#, 叶道有, 臧贺, 范小雪, 邱剑丰, 刘锋, 徐细建, 骆群, 陈大福, 严提珍*, 郭睿*. 东方蜜蜂突触囊泡糖蛋白2B基因的生物信息学和表达模式. 环境昆虫学报, 2024, 已录用.
[25] 徐国钧#，刘小玉#，刘治滩，任亚萍，康婧，宓诗雨，胡艳雯，刘彩珍，陈大福*，郭睿*. 过表达ace-miR-14-y对中华蜜蜂工蜂幼虫靶基因表达及个体和肠道重量的影响. 应用昆虫学报, 2024, 已录用.
[26] 刘小玉#, 刘治滩, 荆欣, 冯佩林, 高旭泽, 吴鹰, 李琪明, 樊念, 陈大福, 付中民, 郭睿*. 意大利蜜蜂AmMETTL3基因的分子克隆与表达模式. 中国农业大学学报, 2024, 29(1): 99-108.
[27] 张凯遥, 赵浩东, 张艺琼, 赵萧, 高旭泽, 邹培缘, 张奎昊, 陈大福, 郭睿*, 牛庆生*. 东方蜜蜂微孢子虫nce-miR-11248及其靶基因SGT1的生物信息学和表达谱研究. 西北农林科技大学学报（自然科学版）, 2024, 52(2), 32-39.
[28] 郭思佳, 张凯遥, 荆欣, 高旭泽, 冯佩林, 邹培缘, 张浩宇, 陈大福,郭睿*,付中民*. 中华蜜蜂细胞吞噬与包囊作用相关基因全长转录本鉴定及分析. 西北农林科技大学学报（自然科学版）, 2024, 52(3), 1-10.
[29] 王思懿, 高旭泽, 赵浩东, 荆欣, 刘小玉, 冯佩林, 宋宇轩, 刘彩珍, 陈大福,郭睿*. 东方蜜蜂微孢子虫侵染过程中 nce-miR-15338及候选靶基因的表达谱. 福建农林大学学报（自然科学版）, 2024, 53(1). DOI: 10.13323/j.cnki.j.fafu(nat.sci.).202301020
[30] 赵萧, 荆欣, 冯佩林, 张艺琼, 任亚萍, 姚雨彤, 黄枳腱, 郭睿*. 东方蜜蜂微孢子虫侵染过程中nce-miR-26675及其靶基因NcSec24的研究. 福建农林大学学报（自然科学版）, 2024, 53(5): 662-670.
[31] 荆欣，胡颖，臧贺，宋宇轩，李坤泽，叶道有，康婧，陈大福，郭睿*. 中华蜜蜂工蜂幼虫肠道自噬与凋亡相关基因及其剪接本鉴定. 福建农林大学学报（自然科学版）, 2024, 53(6): 786-791.
[32] 赵浩东, 王思懿, 李琪明, 张天泽, 陈大福, 郭睿*, 付中民*. 中华蜜蜂酚氧化酶和丝氨酸蛋白酶相关基因及其全长转录本发掘与分析. 安徽农业大学学报, 2024, 已录用.
[33] 刘小玉, 张佳欣, 冯紫莹, 高旭泽, 冯佩林, 蔡宗兵, 李琪明, 那志豪, 陈大福, 郭睿*, 徐国钧*. 中华蜜蜂泛素基因及其全长转录本的发掘及分析. 安徽农业大学学报, 2024, 已录用.
2023年
[1] Kaiyao Zhang#, Zhongmin Fu#, Xiaoxue Fan, Zixin Wang, Siyi Wang, Sijia Guo, Xuze Gao, Haodong Zhao, Xin Jing, Peiyuan Zou, Qiming Li, Mengjun Chen, Dafu Chen*, Rui Guo*.Effect of Ascosphaera apis infestation on the activities of fourantioxidant enzymes in Asian honey bee larval guts. Antioxidants, 2023, 12(1): 206.
[2] Ying Wu#, Yilong Guo#, Xiaoxue Fan, Haodong Zhao, Yiqiong Zhang, Sijia Guo, Xin Jing, Zhitan Liu, Peilin Feng, Xiaoyu Liu, Peiyuan Zou, Qiming Li, Zhihao Na, Kuihao Zhang, Dafu Chen*, Rui Guo*.ame-miR-34 modulates the larval body weight and immuneresponse of apis mellifera workers to Ascosphara apis invasion.International Journal of Molecular Sciences, 2023, 24(2): 1214.
[3] Zixin Wang#, Siyi Wang#, Xiaoxue Fan, Kaiyao Zhang, Jiaxin Zhang, Haodong Zhao, Xuze Gao, Yiqiong Zhang, Sijia Guo, Dingding Zhou, Qiming Li, Zhihao Na, Dafu Chen*, Rui Guo*. Systematic characterization and regulatory role of lncRNAs inAsian honey bees responding to microsporidian infestation. International Journal of Molecular Sciences, 2023, 24(6): 5886.
[4] Rui Guo#, Siyi Wang#, Sijia Guo, Xiaoxue Fan, He Zang, Xuze Gao, Xin Jing, Zhitan Liu, Zhihao Na, Peiyuan Zou, Dafu Chen*. Regulatory roles of long non-coding RNAs relevant toantioxidant enzymes and immune responses of Apis ceranalarvae following Ascosphaera apis invasion. International Journal of Molecular Sciences, 2023, 24(18): 14175.
[5] Xiaoxue Fan#, Xuze Gao#, He Zang, Sijia Guo, Xin Jing, Yiqiong Zhang, Xiaoyu Liu, Peiyuan Zou, Mengjun Chen, Zhijian Huang, Dafu Chen, Rui Guo*.Diverse regulatory manners and potential roles of lncRNAs inthe developmental process of Asian honey bee (Apis cerana)larval guts. International Journal of Molecular Sciences, 2023, 24(20): 15399.
[6] Minghui Sun#, Xiaoxue Fan#, Qi Long, He Zang, Yiqiong Zhang, Xiaoyu Liu, Peilin Feng, Yuxuan Song, Kunze Li, Ying Wu, Haibin Jiang, Dafu Chen, Rui Guo*.First characterization and regulatory function of piRNAs inthe Apis mellifera larval response to Ascosphaera apis invasion. International Journal of Molecular Sciences, 2023, 24(22): 16358.
[7] Xiaoxue Fan#, Wende Zhang#, Sijia Guo, Leran Zhu, Yiqiong Zhang, Haodong Zhao, Xuze Gao, Haibin Jiang, Tianze Zhang, Dafu Chen, Rui Guo*, Qingsheng Niu*. Expression profile, regulatory network, and putative role ofmicroRNAs in the developmental process of Asian honey beelarval guts. Insects, 2023, 14(5): 469.
[8] Yiqiong Zhang#, Xiaoxue Fan#, He Zang, Xiaoyu Liu, Peilin Feng, Daoyou Ye, Leran Zhu, Ying Wu, Haibin Jiang, Dafu Chen, Rui Guo*. Novel insights into the circRNA-modulated developmentalmechanism of western honey bee larval guts. Insects, 2023, 14(11): 897.
[9] 叶亚萍#, 王杰#, 张佳欣, 张凯遥, 顾小雨, 姚雨彤, 任中民, 张扬, 陈大福,郭睿*. 环状RNA ame-circ-000115调节蜜蜂球囊菌胁迫下意大利蜜蜂幼虫肠道基因表达. 生物工程学报, 2023, 39(1): 217-230.
[10] 王紫馨#, 张文德#, 张佳欣, 赵萧, 范小雪, 荆欣, 高旭泽, 陈大福*, 郭睿*. 东方蜜蜂微孢子虫侵染过程中nce-miR-34537和靶基因PIP5KI的表达谱. 微生物学报, 2023, 63(2): 731-744.
[11] 付中民#, 顾小雨#, 胡颖, 赵浩东, 祝智威, 张浩宇, 吉挺, 牛庆生, 陈大福, 郭睿*. LncRNA13164通过ace-miR-4968-y调节中华蜜蜂幼虫对蜜蜂球囊菌侵染的免疫应答. 微生物学报, 2023, 63(03): 1047-1059.
[12] 孙明会#, 张佳欣#, 张艺琼, 赵浩东, 荆欣, 高旭泽, 郭思佳, 冯佩林, 刘小玉, 陈大福, 付中民*, 郭睿*. 东方蜜蜂微孢子虫N6-腺苷特异性甲基化转移酶基因的克隆、分子特性及表达模式. 微生物学报, 2023, 63(8): 3279-3291.
[13] 孙明会#, 钱加珺#, 李琪明, 张天泽, 张佳欣, 赵浩东, 张奎昊, 朱乐冉, 陈田, 陈大福, 付中民*, 郭睿*. 东方蜜蜂微孢子虫类甲基转移酶样蛋白5基因NcMettl5的克隆、分子特性与表达模式. 菌物学报, 2023, 42(5): 1102-1113.
蔡宗兵#, 王紫馨#, 吴鹰, 王思懿, 钱加珺, 胡颖, 张凯遥, 顾小雨, 徐细建, 骆群, [14] 陈大福*, 郭睿*. 中华蜜蜂细胞色素P450基因及其全长转录本的鉴定及分析. 昆虫学报, 2023, 66(1): 11-18.
[15] 王紫馨#, 许雅静#, 张文德, 张凯遥, 吴鹰,刘佳美, 朱乐冉, 牛庆生, 赵红霞, 陈大福*, 郭睿*. ame-miR-14在意大利蜜蜂工蜂幼虫肠道发育过程的调控作用. 昆虫学报, 2023, 66(1): 1-10.
[16] 张凯遥#, 张文德#, 王紫馨, 胡颖, 钱加珺, 王思懿, 赵浩东, 顾小雨, 牛庆生, 付中民, 陈大福*, 郭睿*. 东方蜜蜂微孢子虫侵染意大利蜜蜂工蜂过程中nce-miR-10660及其靶基因表达谱. 昆虫学报, 2023, 66(2): 181-189.
[17] 范小雪#, 张凯遥#, 朱乐冉, 王紫馨, 张奎昊, 牛庆生, 徐细建, 骆群, 陈大福*, 郭睿*.意大利蜜蜂丝氨酸/苏氨酸蛋白激酶基因和全长转录本鉴定及验证. 昆虫学报, 2023, 66(4): 478-485.
[18] 郭意龙#, 赵萧#, 张天泽, 宋宇轩, 赵浩东, 范小雪, 任中民, 张婕, 赵红霞,徐细建, 陈大福*, 郭睿*. 西方蜜蜂几丁质合成酶基因的生物信息学分析及功能研究. 昆虫学报, 2023, 66(4): 469-477.
[19] 吴鹰#, 刘治滩#, 赵浩东, 郭思佳, 刘小玉, 张艺琼, 冯佩林, 赵红霞, 徐细建, 陈大福, 付中民*, 郭睿*. 西方蜜蜂m6A甲基转移酶的基因克隆、多克隆抗体制备及表达模式. 昆虫学报, 2023, 66(7): 885-895.
[20] 张文德#, 胡颖#, 张凯遥, 钱加珺, 赵红霞, 吉挺, 蔺哲广, 陈大福*, 郭睿*. 东方蜜蜂微孢子虫侵染意大利蜜蜂工蜂过程的nce-miR-23928及其靶基因表达谱. 微生物学通报, 2023, 50(1): 185-193.
[21] 吴鹰#, 叶亚萍#, 钱加珺, 张佳欣, 顾小雨, 牛庆生, 陈大福*, 郭睿*. 过表达和敲降ace-miR-3759-y对中华蜜蜂幼虫靶基因表达及体重的影响. 应用昆虫学报, 2023, 60(1): 87-95.
[22] 叶亚萍#, 高旭泽#, 樊念, 张佳欣, 赵浩东, 钱加珺, 张文德, 赵红霞, 徐细建, 陈大福*, 郭睿*. 东方蜜蜂微孢子虫γ-tubulin基因的表达验证与分子特性分析. 应用昆虫学报, 2023, 60(3): 808-815.
[23] 钱加珺#, 荆欣#, 张佳欣, 范小雪, 张文德, 吉挺, 蔺哲广, 陈大福*, 郭睿*. 东方蜜蜂微孢子虫侵染过程中nce-miR-15325及其靶基因NCCS和DTⅢ分析. 应用昆虫学报, 2023, 60(03): 816-824.
[24] 范小雪#, 王思懿#, 朱乐冉, 荆欣, 郭思佳, 牛庆生, 蒋海宾, 徐细建, 陈大福, 付中民, 徐国钧*, 郭睿*. 意大利蜜蜂细胞内吞相关基因与全长转录本鉴定. 应用昆虫学报, 2023, 60 (3): 825-834.
[25] 王思懿#, 胡颖, 刘小玉, 荆欣, 冯佩林, 朱乐冉, 姚雨桐, 陈大福, 郭睿*, 徐国钧*. 东方蜜蜂微孢子虫LCFAL 2基因的分子特性及系统进化分析. 环境昆虫学报, 2023, 45(5): 1284-1290.
[26] 郭意龙#, 张文德#, 陈梦君, 蔡宗兵, 吴鹰, 孙明会, 康育欣, 鲍佳益, 徐细建, 陈大福*, 郭睿*. 意大利蜜蜂工蜂中肠SNP和InDel突变位点的挖掘及分析. 环境昆虫学报, 2023, 45(1): 163-171.
2022年
[1] Huazhi Chen#, Xiaoxue Fan#, Wende Zhang, Yaping Ye, Zongbing Cai, Kaiyao Zhang, Kuihao Zhang, Zhongmin Fu, Dafu Chen*, Rui Guo*. Deciphering the circRNA-regulated response of western honey bee (Apis mellifera) workers to microsporidian invasion. Biology (Basel), 2022, 11(9): 1285.
[2] Yaping Ye#, Xiaoxue Fan#, Zongbing Cai, Ying Wu, Wende Zhang, Haodong Zhao, Sijia Guo, Peilin Feng, Qiming Li, Peiyuan Zou, Mengjun Chen, Nian Fan, Dafu Chen, Rui Guo*. Unveiling the circRNA-mediated immune responses of western honey bee larvae to Ascosphaera apis invasion. International Journal of Molecular Sciences, 2022, 24(1): 613.
[3] Xiaoxue Fan#, Wende Zhang#, Kaiyao Zhang, Jiaxin Zhang, Qi Long, Ying Wu, Kuihao Zhang, Leran Zhu, Dafu Chen*, Rui Guo*. In-depth investigation of microRNA-mediated cross-kingdom regulation between Asian honey bee and microsporidian. Frontiers in Microbiology, 2022, 13: 1003294.
[4] Yaping Ye#, Xiaoxue Fan#, Qi Long, Jie Wang, Wende Zhang, Zongbing Cai, Minghui Sun, Xiaoyu Gu, Peiyuan Zou, Dafu Chen*, Rui Guo*. Comprehensive investigation and regulatory function of lncRNAs engaged in western honey bee larval immune response to Ascosphaera apis invasion. Frontiers in Physiology, 2022, 13:1082522.
[5] Zhiwei Zhu#, Jie Wang#, Xiaoxue Fan, Qi Long, Huazhi Chen, Yaping Ye, Kaiyao Zhang, Zhongmin Ren, Yang Zhang, Qingsheng Niu, Dafu Chen*, Rui Guo*.CircRNA-regulated immune responses of Asian honey bee workers to microsporidian infection. Front in Genetics,2022, 13: 1013239.
[6] Yajing Xu#, Qi Long#, Xiaoxue Fan, Yaping Ye, Kaiyao Zhang, Jiaxin Zhang, Haodong Zhao, Yutong Yao, Zhongmin Fu, Dafu Chen*, Rui Guo*, Ting Ji, Zheguang Lin. Transcriptome-wide characterization of piRNAs during the developmental process of European honey-bee larval guts. Genes(Basel). 2022, 13(10): 1879.
[7] Yuanchan Fan#, Jie Wang#, Kejun Yu, Wende Zhang, Zongbing Cai, Minghui Sun, Ying Hu, Xiao Zhao, Cuiling Xiong, Qingsheng Niu, Dafu Chen*, Rui Guo*. Comparative transcriptome investigation of Nosema ceranae infecting eastern honey bee workers. Insects, 2022, 13(3): 241.
[8] Qilong#, Minghui Sun#, Xiaoxue Fan,Zongbing Cai, Kaiyao Zhang, Siyi Wang1, Jiaxin Zhang, Xiaoyu Gu, Yuxuan Song, Dafu Chen*, Zhongmin Fu*, Rui Guo*, Qingsheng Niu. First identification and investigation of piRNAs in the larval gut of the Asian honeybee, Apis cerana. Insects, 2022, 14(1): 16.
[9] 孙明会#, 刘佳美#, 王思懿, 朱乐冉, 王紫馨, 叶亚萍, 钱加珺, 顾小雨, 徐细建, 陈大福, 郭睿*, 徐国钧*. 结合三代测序与二代测序技术揭示蜜蜂球囊菌孢子转录组的复杂性. 微生物学报, 2022, 62(8): 2981-2994.
[10] 郭意龙#, 余岢骏#, 赵萧, 钱加珺, 赵浩东, 张婕, 张扬, 赵红霞, 徐细建, 骆群, 陈大福*, 郭睿*. 意大利蜜蜂工蜂幼虫nkd基因的生物信息学分析及功能研究. 微生物学报, 2022, 62(12): 5005-5017.
[11] 吴鹰#, 叶亚萍#, 张佳欣, 钱加郡, 张文德, 余岢骏, 吉挺, 蔺哲广, 赵红霞, 陈大福*, 郭睿*.东方蜜蜂微孢子虫侵染意大利蜜蜂工蜂过程中nce-miR-12220及其靶基因的表达谱. 菌物学报, 2022, 41(10): 1546-1557.
[12] 祝智威#, 付中民#, 隆琦, 杜宇, 张文德, 胡颖, 赵萧, 史小玉, 徐细建, 陈大福, 郭睿*. 三种微小RNA在意大利蜜蜂工蜂蛹期发育过程中的表达谱及潜在功能. 昆虫学报, 2022, 65(1): 53-62.
[13] 许雅静#, 吴鹰#, 余岢骏, 孙明会, 刘佳美, 郭意龙, 徐细建, 鲍佳益, 康育欣, 陈大福, 郭睿*, 付中民*. 基于PacBio测序数据的蜜蜂球囊菌转录因子、融合基因及RNA编辑事件的鉴定. 昆虫学报, 2022, 65(1): 63-72.
[14] 蔡宗兵#, 张文德#, 隆琦, 余岢骏, 孙明会, 吴鹰, 许雅静, 刘佳美, 郭意龙, 徐细建, 陈大福*, 郭睿*. 基于PacBio测序数据的蜜蜂球囊菌SNP与InDel位点发掘及分析. 昆虫学报, 2022, 65(2): 187-196.
[15] 祝智威#, 王杰#, 隆琦, 许雅静, 冯睿蓉, 刘佳美, 赵浩东, 朱乐冉, 侯海青, 陈大福*, 郭睿*. 过表达和敲减ame-miR-13b对意大利蜜蜂幼虫肠道内基因表达的影响. 昆虫学报, 2022, 65(4): 460-468.
[16] 范小雪#, 隆琦#, 孙明会, 郭意龙, 赵浩东, 宋岳梅, 康育欣, 顾小雨, 陈大福*, 郭睿*. 意大利蜜蜂工蜂中肠piRNA的鉴定与分析. 昆虫学报, 2022, 65(6): 684-694.
[17] 张文德#, 赵浩东#, 孙明会, 余岢骏, 郭意龙, 朱乐冉, 胡颖, 赵萧, 叶亚萍, 陈大福*, 郭睿*. 东方蜜蜂微孢子虫孢子中微小RNA的鉴定与分析. 昆虫学报, 2022, 65(6): 708-717.
[18] 张凯遥#, 刘佳美#, 张文德, 胡颖, 康育欣, 王紫馨, 王思懿, 钱加珺, 赵萧, 张佳欣, 陈大福, 郭睿*, 付中民*. ame-miR-79负调控意大利蜜蜂工蜂幼虫肠道中靶基因CYP450和FG的表达. 昆虫学报, 2022, 65(10): 1256-1265.
[19] 蔡宗兵#, 王思懿#, 王紫馨, 赵萧, 张凯遥, 郭意龙, 姚雨彤, 钱加珺, 胡颖, 付中民, 陈大福*, 郭睿*. 过表达和敲减ace-miR-3720对中华蜜蜂工蜂幼虫肠道的靶基因表达和重量的影响. 昆虫学报, 2022, 65(10): 1247-1255.
[20] 胡颖#, 张文德#, 王思懿, 张凯遥, 任中民, 吉挺, 蔺哲广, 赵红霞, 陈大福*, 郭睿*. 意大利蜜蜂工蜂幼虫肠道中ame-miR-bantam对靶基因USP和P300的表达调控. 昆虫学报, 2022, 65(11): 1401-1410.
[21] 冯睿蓉#, 付中民#, 杜宇, 张文德, 范小雪, 王海朋, 万洁琦, 周紫彧, 康育欣, 陈大福, 郭睿*, 史培颖*. 中华蜜蜂幼虫肠道中微小RNA的鉴定及分析. 中国农业科学, 2022, 55 (1): 208-218.
[22] 吴鹰#, 蔡宗兵#, 许雅静, 郭意龙, 鲍佳益, 康育欣, 叶亚萍, 钱加珺, 张凯遥, 陈大福*, 郭睿*. 中华蜜蜂的单核苷酸多态性和插入缺失突变位点鉴定. 应用昆虫学报, 2022, 59(3): 608-617.
[23] 张文德#, 蔡宗兵#, 隆琦, 吴鹰, 孙明会, 康育欣, 胡颖, 赵萧, 陈大福*, 郭睿*. 东方蜜蜂微孢子虫的SNP与InDel位点鉴定及分析. 应用昆虫学报, 2022, 59(3): 618-626.
2021年
[1] Wenhao Xing#, Dingding Zhou#, Qi Long, Minghui Sun, Rui Guo*, Limei Wang. Immune response of eastern honeybee worker to Nosema ceranae infection revealed by transcriptomic investigation. Insects,2021, 12(8): 728.
[2] 杜宇#, 王杰#, 蒋海宾, 王秀娜, 范元婵, 范小雪, 祝智威, 隆琦, 张文德, 熊翠玲,郑燕珍, 付中民, 陈大福, 郭睿*. 基于第三代长读段测序数据解析蜜蜂球囊菌基因的可变剪切与可变腺苷酸化. 微生物学报, 2021, 61(3): 667-682.
[3] 陈华枝#, 蒋海宾#, 祝智威, 范元婵, 许雅静, 孙明会, 刘佳美, 熊翠玲, 郑燕珍, 付中民, 徐国钧, 陈大福, 郭睿*. 蜜蜂球囊菌菌丝和孢子中环状RNA的鉴定及比较分析. 微生物学报, 2021, 61(5): 1299-1314.
[4] 杜宇#, 冯睿蓉#, 王杰, 祝智威, 张文德, 余岢骏, 隆琦, 蔡宗兵, 解彦玲, 熊翠玲,郑燕珍, 陈大福, 郭睿*. 中华蜜蜂6日龄幼虫响应蜜蜂球囊菌侵染的长链非编码RNA应答研究. 微生物学报, 2021, 61(5): 1338-1358
[5] 陈华枝#, 范小雪#, 范元婵, 王杰, 祝智威, 蒋海宾, 张文德, 隆琦, 熊翠玲, 郑燕珍, 付中民, 徐国钧, 陈大福, 郭睿*. 东方蜜蜂微孢子虫基因的可变剪接及可变腺苷酸化解析. 菌物学报, 2021, 40(1): 161-173.
[6] 范小雪#, 杜宇#, 张文德, 王杰, 蒋海宾, 范元婵, 冯睿蓉, 万洁琦, 周紫彧, 熊翠玲, 郑燕珍, 陈大福, 郭睿*. 参与调控意大利蜜蜂工蜂中肠基因表达的东方蜜蜂微孢子虫miRNA的组学解析及其调控网络.昆虫学报, 2021, 64(2): 187-204.
[7] 杜宇#, 蒋海宾#, 王杰, 范小雪, 王秀娜, 冯睿蓉, 张文德, 隆琦, 熊翠玲, 郑燕珍, 陈大福, 郭睿*. 蜜蜂球囊菌菌丝和孢子中全长转录本的差异表达分析. 昆虫学报, 2021, 64(3): 363-373.
[8] 周丁丁#, 范元婵#, 王杰, 蒋海宾, 祝智威, 范小雪, 陈华枝, 杜宇, 周紫彧, 熊翠玲, 郑燕珍, 付中民, 陈大福*, 郭睿*. 蜜蜂球囊菌中长链非编码RNA的调控作用. 中国农业科学, 2021, 54 (1): 224-238.
[9] 杜宇#, 祝智威#, 王杰, 王秀娜, 蒋海宾, 范元婵, 范小雪, 陈华枝, 隆琦, 蔡宗兵, 熊翠玲, 郑燕珍, 付中民, 陈大福, 郭睿*. 利用第三代纳米孔长读段测序技术构建和注释蜜蜂球囊菌的全长转录组. 中国农业科学, 2021, 54 (4): 864-876.
[10] 陈华枝#, 范元婵#, 蒋海宾, 王杰, 范小雪, 祝智威, 隆琦, 蔡宗兵, 郑燕珍, 付中民, 徐国钧, 陈大福, 郭睿*. 基于纳米孔全长转录组数据完善东方蜜蜂微孢子虫的基因组注释. 中国农业科学, 2021, 54 (6): 1288-1300.
[11] 杜宇#, 范小雪#, 蒋海宾, 王杰, 冯睿蓉, 张文德, 余岢骏, 隆琦, 蔡宗兵, 熊翠玲, 郑燕珍, 陈大福, 付中民, 徐国钧, 郭睿*. 微小RNA介导意大利蜜蜂工蜂对东方蜜蜂微孢子虫的跨界调控. 中国农业科学, 2021, 54 (8): 1805-1820.
[12] 隆琦#, 余岢骏#, 吴鹰, 孙明会, 冯睿蓉, 赵萧, 胡颖, 徐细建, 付中民, 陈大福*, 郭睿*. 蜜蜂球囊菌菌丝和孢子中毒力因子相关全长转录本的鉴定及分析. 应用昆虫学报, 2021, 58(5): 1073-1082.
2020年
[1] Dafu Chen#, Huazhi Chen#, Yu Du, Zhiwei Zhu, Jie Wang, Sihai Geng, Cuiling Xiong, Yanzhen Zheng, Chunsheng Hou, Qingyun Diao, Rui Guo*. Systematic identification of circular RNAs and corresponding regulatory networks unveil their potential roles in the midguts of eastern honeybee workers. Applied Microbiology and Biotechnology, 2020, 104(1): 257-276.
[2] Dafu Chen#*, Yu Du#, Xiaoxue Fan, Zhiwei Zhu, Haibin Jiang, Jie Wang, Yuanchan Fan, Huazhi Chen, Dingding Zhou, Cuiling Xiong, Yanzhen Zheng, Xijian Xu, Qun Luo, Rui Guo*. Reconstruction and functional annotation of Ascosphaera apis full-length transcriptome utilizing PacBio long reads combined with Illumina short reads. Journal of Invertebrate Pathology, 2020, 176: 107475.
[3] 熊翠玲#, 杜宇#, 冯睿蓉, 蒋海宾, 史小玉, 王海朋, 范小雪, 王杰, 祝智威, 范元婵, 陈华枝, 周丁丁, 郑燕珍, 陈大福*, 郭睿*. 侵染中华蜜蜂6日龄幼虫的蜜蜂球囊菌的微小RNA差异表达谱及调控网络. 微生物学报, 2020, 60(5): 992-1009.
[4] 陈华枝#, 熊翠玲#, 祝智威, 王杰, 范小雪, 蒋海宾, 范元婵, 万洁琦, 卢家轩, 郑燕珍, 付中民, 徐国钧, 陈大福, 郭睿*. 基于small RNA组学分析揭示意大利蜜蜂响应东方蜜蜂微孢子虫胁迫的免疫应答机制. 微生物学报, 2020, 60(7): 1458-1478.
[5] 陈华枝#, 付中民#, 王杰, 祝智威, 范小雪, 蒋海宾, 范元婵, 周丁丁, 李汶东, 熊翠玲, 郑燕珍, 徐国钧, 陈大福, 郭睿*. 中华蜜蜂6日龄幼虫响应蜜蜂球囊菌胁迫的环状RNA应答. 微生物学报, 2020, 60(10): 2292-2310.
[6] 耿四海#, 周丁丁#, 范小雪, 蒋海宾, 祝智威, 王杰, 范元婵, 王心蕊, 熊翠玲, 郑燕珍, 付中民, 陈大福, 郭睿*. 转录组分析揭示东方蜜蜂微孢子虫侵染意大利蜜蜂的分子机制. 昆虫学报, 2020, 63(3): 294-308.
[7] 杜宇#, 付中民#, 祝智威, 王杰, 冯睿蓉, 王秀娜, 蒋海宾, 范元婵, 范小雪, 熊翠玲, 郑燕珍, 徐国钧, 陈大福, 郭睿*. 基于蜜蜂球囊菌纳米孔测序数据的基因非翻译区延长、SSR位点发掘及未注释基因和转录本鉴定. 昆虫学报, 2020, 63(11): 1345-1357.
[8] 陈华枝#, 杜宇#, 范小雪, 祝智威, 蒋海宾, 王杰, 范元婵, 熊翠玲, 郑燕珍, 付中民, 徐国钧, 陈大福, 郭睿*. 基于第三代纳米孔测序技术的东方蜜蜂微孢子虫全长转录组构建及注释. 昆虫学报, 2020, 63(12): 1461-1472.
[9] 杜宇#, 周丁丁#, 万洁琦, 卢家轩, 范小雪, 范元婵, 陈恒, 熊翠玲, 郑燕珍, 付中民, 徐国钧, 陈大福, 郭睿*. 意大利蜜蜂工蜂中肠发育过程中的差异基因表达谱及调控网络. 中国农业科学, 2020, 53 (1): 201-212.
[10] 周丁丁#, 史小玉#, 王杰, 范元婵, 祝智威, 蒋海宾, 范小雪, 熊翠玲, 郑燕珍, 付中民, 徐国钧, 陈大福, 郭睿*. 东方蜜蜂微孢子虫孢子中长链非编码RNA的竞争性内源RNA调控网络及潜在功能. 中国农业科学, 2020, 53 (10): 2122-2136.
[11] 杜宇#, 范小雪#, 蒋海宾, 王杰, 范元婵, 祝智威, 周丁丁, 万洁琦, 卢家轩, 熊翠玲,郑燕珍, 陈大福, 郭睿*. 微小RNA及其介导的竞争性内源RNA调控网络在意大利蜜蜂工蜂中肠发育过程中的潜在作用. 中国农业科, 2020, 53 (12): 2512-2526.
[12] 耿四海#, 石彩云#, 范小雪, 王杰, 祝智威, 蒋海宾, 范元婵, 陈华枝, 杜宇, 王心蕊, 熊翠玲, 郑燕珍, 付中民, 陈大福, 郭睿*. 微小RNA介导东方蜜蜂微孢子虫侵染意大利蜜蜂工蜂的分子机制. 中国农业科学, 2020, 53 (17): 3606-3619.
[13] 陈华枝#, 祝智威#, 蒋海宾, 王杰, 范元婵, 范小雪, 万洁琦, 卢家轩, 熊翠玲, 郑燕珍, 付中民, 陈大福, 郭睿*. 蜜蜂球囊菌菌丝和孢子中微小RNA及其靶mRNA的比较分析. 中国农业科学, 2020, 53 (17): 3606-3619.
2019年
[1] Dafu Chen#, Huazhi Chen#, Yu Du, Dingding Zhou, Sihai Geng, Haipeng Wang, Jieqi Wan, Cuiling Xiong, Yanzhen Zheng, Rui Guo*. Genome-wide identification of long non-coding RNAs and their regulatory networks involved in Apis mellifera ligustica response to Nosema ceranae infection. Insects, 2019, 10(8): 245.
[2] Dafu Chen#, Yu Du #, Huazhi Chen, Yuanchan Fan, Xiaoxue Fan, Zhiwei Zhu, Jie Wang, Cuiling Xiong, Yanzhen Zheng, Chunsheng Hou, Qingyun Diao, Rui Guo*. Comparative identification of microRNAs in Apis cerana cerana workers’ midguts in response to Nosema ceranae invasion. Insects,2019, 10(9): 258.
[3] Rui Guo#*, Dafu Chen#*, Qingyun Diao, Cuiling Xiong, Yanzhen Zheng, Chunsheng Hou. Transcriptomic investigation of immune responses of the Apis cerana cerana larval gut infected by Ascosphaera apis. Journal of Invertebrate Pathology, 2019, 166: 107210.
[4] 杜宇#, 童新宇#, 周丁丁, 陈大福, 熊翠玲, 郑燕珍, 徐国钧, 王海朋, 陈华枝,郭意龙, 隆琦, 郭睿*. 中华蜜蜂幼虫肠道响应球囊菌胁迫的microRNA应答分析. 微生物学报, 2019, 59(9): 1747-1764.
[5] 杜宇#, 童新宇#, 周丁丁, 陈大福, 熊翠玲, 郑燕珍, 徐国钧, 王海朋, 陈华枝, 郭意龙, 隆琦, 郭睿*. 中华蜜蜂幼虫肠道响应球囊菌胁迫的microRNA应答分析. 微生物学报, 2019, 59(9): 1747-1764.
[6] 郭睿#, 杜宇#, 周倪红, 刘思亚, 熊翠玲, 郑燕珍, 付中民, 徐国钧, 王海朋, 耿四海, 周丁丁, 陈大福*. 意大利蜜蜂幼虫肠道在球囊菌胁迫后期的差异表达微小RNA及其靶基因分析.昆虫学报, 2019,62(1): 49-60
[7] 郭睿#, 杜宇#, 童新宇, 熊翠玲, 郑燕珍, 徐国钧, 王海朋, 耿四海, 周丁丁, 郭意龙, 吴素珍, 陈大福*. 意大利蜜蜂幼虫肠道在球囊菌侵染前期的差异表达microRNA及其调控网络. 中国农业科学, 2019, 52 (1): 166-180.
[8] 付中民#, 陈华枝#, 刘思亚, 祝智威, 范小雪, 范元婵, 万洁琦, 张璐, 熊翠玲, 徐国钧, 陈大福, 郭睿*. 意大利蜜蜂响应东方蜜蜂微孢子虫胁迫的免疫应答. 中国农业科学, 2019, 52 (17): 3069-3082.
[9] 熊翠玲#, 童新宇#, 陈华枝, 耿四海, 庄天艺, 郑燕珍, 付中民, 陈大福, 赵红霞, 郭睿*. 东方蜜蜂微孢子虫的基因结构优化及新基因鉴定. 环境昆虫学报, 2019, 41(2): 373-379.
2018年
[1] Rui Guo#*, Dafu Chen#, Cuiling Xiong, Chunsheng Hou, Yanzhen Zheng, Zhongmin Fu, Qin Ling, Qingyun Diao, Lu Zhang, Hongquan Wang, Zhixian Hou, Dhiraj Kumar. First identification of long non-coding RNAs in fungal parasite Nosema ceranae. Apidologie, 2018, 49(5): 660-670.
[2] Rui Guo#*, Dafu Chen#*, Huazhi Chen, Cuiling Xiong, Yanzhen Zheng, Chunsheng Hou, Yu Du, Sihai Geng, Haipeng Wang, Zhou Dingding, Guo Yilong. Genome-wide identification of circular RNAs in fungal parasite Nosema ceranae. Current Microbiology, 2018, 75(12): 1655-1660.
[3] Rui Guo#*, Dafu Chen#*, Huazhi Chen, Zhongmin Fu, Cuiling Xiong, Chunsheng Hou, Yanzhen Zheng, Yilong Gu, Haipeng Wang, Yu Du, Qingyun Diao. Systematic investigation of circular RNAs in Ascosphaera apis a fungal pathogen of honeybee larvae. Gene, 2018, 678: 17-22.
[4] Dafu Chen#*, Rui Guo#*, Cuiling Xiong, Yanzhen Zheng, Chunsheng Hou & Zhongming Fu. Morphological and molecular identification of chalkbrood disease pathogen Ascosphaera apis in Apis cerana cerana. Journal of Apicultural Research
,2018, 57(4): 516-521.
[5] Rui Guo#*, Dafu Chen#*, Cuiling Xiong, Chunsheng Hou, Yanzhen Zheng, Zhongmin Fu, Qingyun Diao, Lu Zhang, Hongquan Wang, Zhixian Hou, Wendong Li, Dhiraj Kuma, Qin Liang. Identification of long non-coding RNAs in the chalkbrood disease pathogen Ascospheara apis. Journal of Invertebrate Pathology, 2018, 156: 1-5.
[6] 郭睿#, 王海朋#, 陈华枝, 熊翠玲, 郑燕珍, 付中民, 赵红霞, 陈大福*. 蜜蜂球囊菌的microRNA鉴定及其调控网络分析. 微生物学报, 2018, 58(6): 1077-1089.
[7] 熊翠玲#, 陈华枝#, 陈大福, 郑燕珍, 付中民, 徐国钧, 杜宇, 王海朋, 耿四海, 周丁丁, 刘思亚, 郭睿*. 意大利蜜蜂工蜂中肠的环状RNA及其调控网络分析. 昆虫学报, 2018, 61(12): 1363-1375.
[8] 郭睿#, 耿四海#, 熊翠玲, 郑燕珍, 付中民, 王海朋, 杜宇, 童新宇, 赵红霞, 陈大福*. 意大利蜜蜂工蜂中肠发育过程中长链非编码RNA的差异表达分析. 中国农业科学, 2018, 51 (18): 3600-3613.
[9] 郭睿#, 杜宇#, 熊翠玲, 郑燕珍, 付中民, 徐国钧, 王海朋, 陈华枝, 耿四海, 周丁丁, 石彩云, 赵红霞, 陈大福*. 意大利蜜蜂幼虫肠道发育过程中的差异表达microRNA及其调控网络. 中国农业科学, 2018, 51 (21): 4197-4209.
[10] 郭睿#, 陈华枝#, 熊翠玲, 郑燕珍, 付中民, 徐国钧, 杜宇, 王海朋, 耿四海, 周丁丁, 刘思亚, 陈大福*. 意大利蜜蜂工蜂中肠发育过程中的差异表达环状RNA及其调控网络分析. 中国农业科学, 2018, 51 (23): 4575-4590.
[11] 郭睿#, 李汶东#, 陈大福*, 熊翠玲, 郑燕珍, 付中民, 徐细建, 黄枳腱, 骆群.意大利蜜蜂幼虫肠道内球囊菌及其纯培养的高表达基因差异分析. 微生物学通报, 2018, 45(2): 368-375.
[12] 熊翠玲#, 杜宇#, 陈大福, 郑燕珍, 付中民, 王海朋, 耿四海, 陈华枝, 周丁丁, 吴素珍, 石彩云, 郭睿*. 意大利蜜蜂幼虫肠道的miRNAs的生物信息学预测及分析. 应用昆虫学报, 2018, 55(6): 1023-1033.
[13] 熊翠玲#,耿四海#, 王心蕊, 刘思亚, 陈大福, 郑燕珍, 付中民, 杜宇, 王海朋, 陈华枝, 周丁丁, 郭睿*. 意大利蜜蜂工蜂中肠的长链非编码 RNA的预测、分析及鉴定. 应用昆虫学报, 2018, 55(6): 1034-1044.
[14] 郭睿#, 刀晨#, 熊翠玲, 郑燕珍, 付中民, 耿四海, 陈大福*. 意大利蜜蜂工蜂中肠响应Nosema ceranae胁迫的高表达基因分析. 环境昆虫学报, 2018, 40(5): 1106-1112.
2017年
[1] Dafu Chen#*, Rui Guo#*, Xijian Xu, Cuiling Xiong, Qin Liang, Yanzhen Zheng, Qun Luo, Zhaonan Zhang, Zhijian Huang, Dhiraj Kumar, Weijun Xi, Xuan Zou, Min Liu. Uncovering the immune responses of Apis mellifera ligustica larval gut to Ascosphaera apis infection utilizing transcriptome sequencing. Gene, 2017, 621: 40-50.
[2] 郭睿#, 陈大福#*, 黄枳腱, 梁勤, 熊翠玲, 徐细建, 郑燕珍, 张曌楠, 解彦玲,童新宇, 侯志贤, 江亮亮, 刀晨. 球囊菌胁迫中华蜜蜂幼虫肠道过程中病原的转录组学研究. 微生物学报, 2017, 57(12): 1865-1878.
[3] 张曌楠#, 熊翠玲#, 徐细建, 黄枳腱, 郑燕珍, 骆群, 刘敏, 李汶东, 童新宇, 张琦, 梁勤, 郭睿*, 陈大福*. 蜜蜂球囊菌的参考转录组de novo组装及SSR分子标记开发. 昆虫学报, 2017, 60(1): 34-44.
[4] 陈大福#, 郭睿#,*, 熊翠玲#, 梁勤, 郑燕珍, 徐细建, 黄枳腱, 张曌楠, 张璐 , 李汶东, 童新宇, 席伟军. 胁迫意大利蜜蜂幼虫肠道的球囊菌的转录组分析.昆虫学报, 2017, 60(4): 401-411.
[5] 徐细建#, 郭睿#, 骆群, 熊翠玲, 梁勤, 张串联, 郑燕珍, 张曌楠, 黄枳腱, 张璐,李汶东, 陈大福*. 中华蜜蜂幼虫肠道参考转录组的de novo组装及SSR分子标记鉴定. 中国农业科学, 2017, 50 (6): 1157-1167.
[6] 陈大福, 郭睿*, 熊翠玲, 梁勤, 郑燕珍, 徐细建, 张曌楠, 黄枳腱, 张璐, 王鸿权, 解彦玲, 童新宇. 中华蜜蜂幼虫肠道响应球囊菌早期胁迫的转录组学. 中国农业科学, 2017, 50 (13): 2614-2623.
[7] 郭睿#, 熊翠玲#, 郑燕珍, 张璐, 童新宇, 梁勤*, 陈大福*. 意大利蜜蜂幼虫肠道响应球囊菌早期胁迫的转录组学分析. 应用昆虫学报, 2017, 54(4): 553-560.
[8] 熊翠玲#, 张璐#, 付中民, 王鸿权, 侯志贤, 童新宇, 李汶东, 郑燕珍，陈大福*，郭睿*. 基于RNA-seq数据大规模开发中华蜜蜂幼虫的SSR分子标记.环境昆虫学报, 2017, 39(1): 68-74.
[9] 郭睿, 张璐, 徐细建, 史秀丽, 熊翠玲, 郑燕珍, 付中民, 黄枳腱, 王鸿权, 侯志贤, 陈大福*, 中华蜜蜂6日龄幼虫肠道响应球囊菌胁迫的差异表达基因分析. 环境昆虫学报, 2017, 39(3): 539-547.
Curriculum Vitae
Rui Guo, Ph. D., Associate Professor, Doctoral Supervisor
National & Local United Engineering Laboratory of Natural Biotoxin
Apitherapy Research Institute
College of Bee Science and Biomedicine
Fujian Agriculture and Forestry University
Fuzhou 350002, China
Phone: 0086-0591-87640197; 0086-15205080780
WeChat: dt15205080780
Fax: 0086-0591-87640197
E-mail: ruiguo@fafu.edu.cn; fafu_ruiguo@126.com
RESEARCHINTERESTS:
l Insect Molecular Biology and Biochemistry (honeybee and silkworm)
l Non-coding RNAs of Insect (circRNA, lncRNA, miRNA, piRNA, siRNA)
l Genetics and Epigenetics of Insect (DNA methylation and RNA methylation)
l Omics of Insect (genomics, transcriptomics, proteomics, metabo, etc.)
l Insect Protection (pathogenesis, biological prevention and control)
l Mechanism of anti-tumor/anti-inflammation effect of melittin
l Precision Medicine
ACADEMIC QUALIFICATIONS:
l Ph.D. in Special Animal Farming, Soochow University, China.
l M.S. in Microbiology, Soochow University, China.
l B.S. in Life Science, Huaibei Normal University, China.
ACADEMIC AWARDS:
l The most influential scholar in China
l The Top 1% highly cited scholar in China
l The candidate for 1st “” project of Fujian Agriculture and Forestry University
l The outstanding young scientific talent of Fujian Agriculture and Forestry University
l The prominent teacher of Fujian Agriculture and Forestry University
l The prominent class advisor of Fujian Agriculture and Forestry University
l The Youth May 4th Medal of Fujian Agriculture and Forestry University
l 2023 Top view paper in the journal International Journal of Molecular Sciences
l Top academic articles in Chinese quality science and technology journals (5 articles)
l Annual excellent paper in the journal Acta Microbiologica Sinica
l Annual excellent paper in the journal Mycosystema
RESEARCH EXPERIENCE:
Our research team mainly focuses on molecular biology, omics, and protection of important economic insects such as honeybee and silkworm. In the last decade, our group has made an array of original advances in immune response of insect host to pathogen invasion, pathogenesis of widespread fungal pathogens of honeybees, regulatory function and mechanism of non-coding RNAs in honeybees and their pathogens, and transgene of silkworm’s virus and microsporidian. In recent years, we have conducted in-depth investigation of the effect of api-products (bee venom, propolis, royal jelly, honey) on various human tumors and inflammation as well as the underlying mechanisms, opening the new door for precision detection and therapy of human diseases.
(1) We systematically investigated the immune responses of eastern honeybee larvae and western honeybee larvae to Ascosphaera apis infection, ****yzed the gene expression patterns of A. apis during chalkbrood disease, and revealed the underlying molecular mechanisms.
(2) We first made genome-wide identification of circRNAs, lncRNAs, and miRNAs in A. apis, and confirmed their expression using molecular approaches.
(3) We comprehensively ****yzed the non-coding RNA-mediated immune responses and corresponding regulatory networks of western honeybee worker to Nosema ceranae invasion, and further uncovered the miRNA-mediated mechanism regulating the host-pathogen interaction during microsporidiosis.
(4) Based on next-generation sequencing and bioinformatics, we first identified and characterized circRNAs and lncRNAs in N. ceranae, and circRNAs in Apis cerana cerana, a subspecies of eastern honeybee.
(5) Utilizing the up-to-date third-generation sequencing such as PacBio SMRT sequencing and Oxford Nanopore long-read sequencing, we first constructed and annotated the full-length transcriptomes, surveyed the alternative splicing and alternative polyadenylation, and improved the current reference genomes of A. apis and N. ceranae.
(6) We successfully assembled and annotated a chromosome-level genome of N. ceranae on basis of high-quality data generated form PacBio SMRT sequencing.
(7) Using molecular cloning and in vitro transcription, a recombinant Bombyx mori cypovirus (BmCPV) was successfully constructed, and the construction system was demonstrated to be a powerful platform for exploration of viral replication and pathogenesis.
(8) Based on transfection of BmN cells with recombinant plasmid and Bac-to-Bac system, we successfully developed a protocol to study the gene function of Bombyx mori bidensovirus (BmBDV), providing a new way for exploitation of effective and eco-friendly pesticide.
(9) We developed a novel method of inserting exogenous gene into N. bombycis genome mediated by a non-transposon vector, offering a valuable reference for constructing genetically modified microsporidia used in bio-control of pest.
ACADEMIC PARTICIPATION
(1) Beekeeping Association of Fujian Province, Deputy secretary general, council member
(2) Biomolecules, Review Editor
(3) Frontiers in Bee Science, Review Editor
(4) Journal of Environmental Entomology, Editor
(5) Veterinary Science, Guest Editor
(6) Life, Guest Editor
(7) Genes, Guest Editor
(8) Frontiers in Physiology, Guest Editor
(9) Frontiers in Genetics, Guest Editor
(10) Journal of Anhui Agriculture University, Youth Editor
(11) Journal of Hazardous Materials, RNA Biology, Microbiological Spectrum, Parasitology Research, Gene, Microbial Ecology, Frontiers in Cellular and Infection Microbiology, Frontiers in Microbiology, Frontiers in Ecology and Evolution, Biomolecules, International Journal of Molecular Sciences, Life, Insects, Journal of Asian-Pacific Entomology, Veterinary Sciences, Genes, Pathogens, Microorganisms, BioTech, Reviewer
RESEARCH PROJECT
(1) National Natural Science Foundation of China (32372943), Leader
(2) National Natural Science Foundation of China (31702190), Leader
(3) National Natural Science Foundation of China (32172792),Key member
(4) Earmarked Fund for China Agriculture Research System (CARS-44-KXJ7), Key member
(5) Natural Science Foundation of Fujian Province (2022J01133), Leader
(6) Natural Science Foundation of Fujian Province (2018J05042), Leader
(7) Teaching and Scientific Research Fund of Education Department of Fujian Province (JAT170158), Leader
(8) Outstanding Scientific Research Manpower Fund of Fujian Agriculture and Forestry University (xjq201814), Leader
(9) Master Supervisor Team Fund of Fujian Agriculture and Forestry University (Honeybee-Pathogen Interaction Research Team), Leader
(10) Scientific and Technical Innovation Fund of Fujian Agriculture and Forestry University (CXZX2017342), Leader
(11) Open Fund of Key Laboratory of Pollinating Insect Biology of Ministry of Agriculture and Rural Affairs (2017MFNZS02), Leader
(12) Open Project of Key laboratory of pathogenic fungus and fungal toxin of Fujian province, Leader
REPRESENTIVE ACADEMIC JOURNAL ARTICLES:
[1] Yuxuan Song#, Jianfeng Qiu#, Jing Kang, Ying Chen, Ruihua Cao, Wei Wang, Mengyuan Dai, Dafu Chen, Zhongmin Fu, Rui Guo*. Transcriptomic characterization of miRNAs in Apis cerana larvae responding to Ascosphaera apis infection. Genes, 2025, 16(2): 156.
[2] Xiaoxue Fan#, Haodong Zhao#, He Zang#, Shunan Dong, Jianfeng Qiu, Yuxuan Song, Kunze Li, Haibin Jiang, Ying Wu, Yang Lü, Dingding Zhou, Zhongmin Fu, Dafu Chen, Rui Guo*. Extensive influence of microsporidian infection on sucrose solution consumption, antioxidant enzyme activity, cell structure, and lifespan of Asian honeybees. Frontiers in Immunology, 2024, 15: 1404766
[3]Rui Guo#, Kaiyao Zhang#, He Zang, Sijia Guo, Xiaoyu Liu, Xin Jing, Yuxuan Song, Kunze Li, Ying Wu, Haibing Jiang, Zhongmin Fu, Dafu Chen*. Dynamics and regulatory role of circRNAs in Asian honey bee larvae following fungal infection. Applied Microbiology and Biotechnology, 2024, 108: 261.
[4] Xiaoxue Fan#, Xuze Gao#, He Zang, Zhitan Liu, Xin Jing, Xiaoyu Liu, Sijia Guo, Haibing Jiang, Ying Wu, Zhijian Huang, Dafu Chen, Rui Guo*. Transcriptional dynamics and regulatory role of miRNAs in Ascosphaera apis invading western honey bee (Apis mellifera) larvae. Frontiers in Microbiology, 2024, 15: 1355035.
[5] Xuze Gao#, He Zang#, Xiaoyu Liu, Sijia Guo, Daoyou Ye, Zhitan Liu, Xin Jing, Qingsheng Niu, Ying Wu, Yang Lü, Dafu Chen, Rui Guo*. Unraveling the modulatory manner and function of circRNAs in the Asian honey bee larval guts. Frontiers in Cell and Developmental Biology, 2024, 12: 13917107.
[6] Shunan Dong#, Kunze Li#, He Zang, Yuxuan Song, Jing Kang, Ying Chen, Liting Du, Ning Wang, Dafu Chen, Qingming Luo, Tizhen Yan*, Rui Guo*, Jianfeng Qiu*. ame-miR-5119-Eth axis modulates larval-pupal transition of western honeybee worker. Frontiers in Physiology, 2024, 15: 1475306.
[7] He Zang#, Sijia Guo#, Shunan Dong, Yuxuan Song, Kunze Li, Xiaoxue Fan, Jianfeng Qiu, Yidi Zheng, Haibin Jiang, Ying Wu, Yang Lü, Dafu Chen, Rui Guo*. Construction of a full-length transcriptome of western honeybee midgut tissue and improved genome annotation. Genes, 2024, 15: 728.
[8] Sijia Guo#, He Zang#, Xiaoyu Liu, Xin Jing, Zhitan Liu, Wende Zhang, Mengyi Wang, Yidi Zheng, Zhengyuan Li, Jianfeng Qiu, Dafu Chen, Tizhen Yan*, Rui Guo*. Full-length transcriptome construction and systematic characterization of virulence factor-associated isoforms in Vairimorpha (Nosema) ceranae. Genes, 2014, 15: 111.
[9] Kaiyao Zhang#, Zhongmin Fu#, Xiaoxue Fan, Zixin Wang, Siyi Wang, Sijia Guo, Xuze Gao, Haodong Zhao, Xin Jing, Peiyuan Zou, Qiming Li, Mengjun Chen, Dafu Chen*, Rui Guo*. Effect of Ascosphaera apis infestation on the activities of fourantioxidant enzymes in Asian honey bee larval guts. Antioxidants, 2023, 12(1): 206.
[10] Ying Wu#, Yilong Guo#, Xiaoxue Fan, Haodong Zhao, Yiqiong Zhang, Sijia Guo, Xin Jing, Zhitan Liu, Peilin Feng, Xiaoyu Liu, Peiyuan Zou, Qiming Li, Zhihao Na, Kuihao Zhang, Dafu Chen*, Rui Guo*. ame-miR-34 modulates the larval body weight and immuneresponse of Apis mellifera workers to Ascosphara apis invasion.International Journal of Molecular Sciences, 2023, 24(2): 1214.
[11] Zixin Wang#, Siyi Wang#, Xiaoxue Fan, Kaiyao Zhang, Jiaxin Zhang, Haodong Zhao, Xuze Gao, Yiqiong Zhang, Sijia Guo, Dingding Zhou, Qiming Li, Zhihao Na, Dafu Chen*, Rui Guo*. Systematic characterization and regulatory role of lncRNAs inAsian honey bees responding to microsporidian infestation. International Journal of Molecular Sciences, 2023, 24(6): 5886.
[12] Rui Guo#, Siyi Wang#, Sijia Guo, Xiaoxue Fan, He Zang, Xuze Gao, Xin Jing, Zhitan Liu, Zhihao Na, Peiyuan Zou, Dafu Chen*. Regulatory roles of long non-coding RNAs relevant toantioxidant enzymes and immune responses of Apis ceranalarvae following Ascosphaera apis invasion. International Journal of Molecular Sciences, 2023, 24(18): 14175.
[13] Xiaoxue Fan#, Xuze Gao#, He Zang, Sijia Guo, Xin Jing, Yiqiong Zhang, Xiaoyu Liu, Peiyuan Zou, Mengjun Chen, Zhijian Huang, Dafu Chen, Rui Guo*. Diverse regulatory manners and potential roles of lncRNAs inthe developmental process of Asian honey bee (Apis cerana)larval guts. International Journal of Molecular Sciences, 2023, 24(20): 15399.
[14] Minghui Sun#, Xiaoxue Fan#, Qi Long, He Zang, Yiqiong Zhang, Xiaoyu Liu, Peilin Feng, Yuxuan Song, Kunze Li, Ying Wu, Haibin Jiang, Dafu Chen, Rui Guo*. First characterization and regulatory function of piRNAs intheApis mellifera larval response to Ascosphaera apis invasion. International Journal of Molecular Sciences, 2023, 24(22): 16358.
[15] Xiaoxue Fan#, Wende Zhang#, Sijia Guo, Leran Zhu, Yiqiong Zhang, Haodong Zhao, Xuze Gao, Haibin Jiang, Tianze Zhang, Dafu Chen, Rui Guo*, Qingsheng Niu*. Expression profile, regulatory network, and putative role ofmicroRNAs in the developmental process of Asian honey beelarval guts. Insects, 2023, 14(5): 469.
[16] Yiqiong Zhang#, Xiaoxue Fan#, He Zang, Xiaoyu Liu, Peilin Feng, Daoyou Ye, Leran Zhu, Ying Wu, Haibin Jiang, Dafu Chen, Rui Guo*. Novel insights into the circRNA-modulated developmentalmechanism of western honey bee larval guts. Insects, 2023, 14(11): 897.
[17] Huazhi Chen#, Xiaoxue Fan#, Wende Zhang, Yaping Ye, Zongbing Cai, Kaiyao Zhang, Kuihao Zhang, Zhongmin Fu, Dafu Chen*, Rui Guo*. Deciphering the circRNA-regulated response of western honey bee (Apis mellifera) workers to microsporidian invasion. Biology (Basel), 2022, 11(9): 1285.
[18] Yaping Ye#, Xiaoxue Fan#, Zongbing Cai, Ying Wu, Wende Zhang, Haodong Zhao, Sijia Guo, Peilin Feng, Qiming Li, Peiyuan Zou, Mengjun Chen, Nian Fan, Dafu Chen, Rui Guo*. Unveiling the circRNA-mediated immune responses of western honey bee larvae to Ascosphaera apis invasion. International Journal of Molecular Sciences, 2022, 24(1): 613.
[19] Xiaoxue Fan#, Wende Zhang#, Kaiyao Zhang, Jiaxin Zhang, Qi Long, Ying Wu, Kuihao Zhang, Leran Zhu, Dafu Chen*, Rui Guo*. In-depth investigation of microRNA-mediated cross-kingdom regulation between Asian honey bee and microsporidian. Frontiers in Microbiology, 2022, 13: 1003294.
[20] Yaping Ye#, Xiaoxue Fan#, Qi Long, Jie Wang, Wende Zhang, Zongbing Cai, Minghui Sun, Xiaoyu Gu, Peiyuan Zou, Dafu Chen*, Rui Guo*. Comprehensive investigation and regulatory function of lncRNAs engaged in western honey bee larval immune response to Ascosphaera apis invasion. Frontiers in Physiology, 2022, 13:1082522.
[21] Zhiwei Zhu#, Jie Wang#, Xiaoxue Fan, Qi Long, Huazhi Chen, Yaping Ye, Kaiyao Zhang, Zhongmin Ren, Yang Zhang, Qingsheng Niu, Dafu Chen*, Rui Guo*.CircRNA-regulated immune responses of Asian honey bee workers to microsporidian infection. Front in Genetics,2022, 13: 1013239.
[22] Yajing Xu#, Qi Long#, Xiaoxue Fan, Yaping Ye, Kaiyao Zhang, Jiaxin Zhang, Haodong Zhao, Yutong Yao, Zhongmin Fu, Dafu Chen*, Rui Guo*, Ting Ji, Zheguang Lin. Transcriptome-wide characterization of piRNAs during the developmental process of European honey-bee larval guts. Genes(Basel). 2022, 13(10): 1879.
[23] Yuanchan Fan#, Jie Wang#, Kejun Yu, Wende Zhang, Zongbing Cai, Minghui Sun, Ying Hu, Xiao Zhao, Cuiling Xiong, Qingsheng Niu, Dafu Chen*, Rui Guo*. Comparative transcriptome investigation of Nosema ceranae infecting eastern honey bee workers. Insects, 2022, 13(3): 241.
[24] Qilong#, Minghui Sun#, Xiaoxue Fan,Zongbing Cai, Kaiyao Zhang, Siyi Wang1, Jiaxin Zhang, Xiaoyu Gu, Yuxuan Song, Dafu Chen*, Zhongmin Fu*, Rui Guo*, Qingsheng Niu. First identification and investigation of piRNAs in the larval gut of the Asian honeybee, Apis cerana. Insects, 2022, 14(1): 16.
[25] Wenhao Xing#, Dingding Zhou#, Qi Long, Minghui Sun, Rui Guo*, Limei Wang. Immune response of eastern honeybee worker to Nosema ceranae infection revealed by transcriptomic investigation. Insects,2021, 12(8): 728.
[26] Dafu Chen#, Huazhi Chen#, Yu Du, Zhiwei Zhu, Jie Wang, Sihai Geng, Cuiling Xiong, Yanzhen Zheng, Chunsheng Hou, Qingyun Diao, Rui Guo*. Systematic identification of circular RNAs and corresponding regulatory networks unveil their potential roles in the midguts of eastern honeybee workers. Applied Microbiology and Biotechnology, 2020, 104(1): 257-276.
[27] Dafu Chen#*, Yu Du#, Xiaoxue Fan, Zhiwei Zhu, Haibin Jiang, Jie Wang, Yuanchan Fan, Huazhi Chen, Dingding Zhou, Cuiling Xiong, Yanzhen Zheng, Xijian Xu, Qun Luo, Rui Guo*. Reconstruction and functional annotation of Ascosphaera apis full-length transcriptome utilizing PacBio long reads combined with Illumina short reads. Journal of Invertebrate Pathology, 2020, 176: 107475.
[28] Dafu Chen#, Huazhi Chen#, Yu Du, Dingding Zhou, Sihai Geng, Haipeng Wang, Jieqi Wan, Cuiling Xiong, Yanzhen Zheng, Rui Guo*. Genome-wide identification of long non-coding RNAs and their regulatory networks involved in Apis mellifera ligustica response to Nosema ceranae infection. Insects, 2019, 10(8): 245.
[29] Dafu Chen#, Yu Du #, Huazhi Chen, Yuanchan Fan, Xiaoxue Fan, Zhiwei Zhu, Jie Wang, Cuiling Xiong, Yanzhen Zheng, Chunsheng Hou, Qingyun Diao, Rui Guo*. Comparative identification of microRNAs in Apis cerana cerana workers’ midguts in response to Nosema ceranae invasion. Insects,2019, 10(9): 258.
[30] Rui Guo#*, Dafu Chen#*, Qingyun Diao, Cuiling Xiong, Yanzhen Zheng, Chunsheng Hou. Transcriptomic investigation of immune responses of the Apis cerana cerana larval gut infected by Ascosphaera apis. Journal of Invertebrate Pathology, 2019, 166: 107210.
[31] Rui Guo#*, Dafu Chen#, Cuiling Xiong, Chunsheng Hou, Yanzhen Zheng, Zhongmin Fu, Qin Ling, Qingyun Diao, Lu Zhang, Hongquan Wang, Zhixian Hou, Dhiraj Kumar. First identification of long non-coding RNAs in fungal parasite Nosema ceranae. Apidologie, 2018, 49(5): 660-670.
[32] Rui Guo#*, Dafu Chen#*, Huazhi Chen, Cuiling Xiong, Yanzhen Zheng, Chunsheng Hou, Yu Du, Sihai Geng, Haipeng Wang, Zhou Dingding, Guo Yilong. Genome-Wide Identification of Circular RNAs in Fungal Parasite Nosema ceranae. Current Microbiology, 2018, 75(12): 1655-1660.
[33] Rui Guo#*, Dafu Chen#*, Huazhi Chen, Zhongmin Fu, Cuiling Xiong, Chunsheng Hou, Yanzhen Zheng, Yilong Gu, Haipeng Wang, Yu Du, Qingyun Diao. Systematic investigation of circular RNAs in Ascosphaera apis a fungal pathogen of honeybee larvae. Gene, 2018, 678: 17-22.
[34] Dafu Chen#*, Rui Guo#*, Cuiling Xiong, Yanzhen Zheng, Chunsheng Hou & Zhongming Fu. Morphological and molecular identification of chalkbrood disease pathogen Ascosphaera apis in Apis cerana cerana. Journal of Apicultural Research
,2018, 57(4): 516-521.
[35] Rui Guo#*, Dafu Chen#*, Cuiling Xiong, Chunsheng Hou, Yanzhen Zheng, Zhongmin Fu, Qingyun Diao, Lu Zhang, Hongquan Wang, Zhixian Hou, Wendong Li, Dhiraj Kuma, Qin Liang. Identification of long non-coding RNAs in the chalkbrood disease pathogen Ascospheara apis. Journal of Invertebrate Pathology, 2018, 156: 1-5.
[36] Dafu Chen#*, Rui Guo#*, Xijian Xu, Cuiling Xiong, Qin Liang, Yanzhen Zheng, Qun Luo, Zhaonan Zhang, Zhijian Huang, Dhiraj Kumar, Weijun Xi, Xuan Zou, Min Liu. Uncovering the immune responses of Apis mellifera ligustica larval gut to Ascosphaera apis infection utilizing transcriptome sequencing. Gene, 2017, 621: 40-50.
(Note: * Corresponding author, # Co-first author)
CONTACT INFORMATION:
Associate Prof. Dr. Rui Guo
National & Local United Engineering Laboratory of Natural Biotoxin
Apitherapy Research Institute
College of Bee Science and Biomedicine
Fujian Agriculture and Forestry University
NO. 15,RdShangxiadian, Cangshan District,
Fuzhou city, Fujian province, China
Phone: +86-0591-87640197; +86-15205080780
E-mails: ruiguo@fafu.edu.cn; fafu_ruiguo@126.com