高江涛

高江涛

基本信息

教育经历

工作经历

2015.3-现在  福建农林大学闽江特聘教授

2011.1-2014.12 美国伊利诺伊大学香槟分校， 博士后， 合作导师： Wilfred van der Donk (美国科学院院士, 美国文理学院院士)

研究兴趣 

天然药物化学，中药学，合成生物学，化学生物学，蛋白质工程, 生物合成, 酶工程等

获奖经历 

2018 福建高层次才B类

2015 闽江特聘教授

经费资助:

1.     国家重点研发计划. 骨架相关酶元件的工程化改造. NO. 2021YFA0910502. 2021/12-2026/12. ¥4,720,000. 课题负责人.

2.     自然基金面上项目. 链霉菌Streptomyces sp. G0051B 中膦酸类抗生素ArgolaphosA的生物合成研究.NO. 31870050. 2019/01-20222/12. ¥ 590,000.00.  课题负责人.

3.     上海交通大学微生物代谢国家重点实验室2020 年开放课题.基于合成生物学策略对膦酸类化合物Valinophos 产量的工程优化. NO.MMLKF20-02. 2020/06-2022/6. ¥80,000.00. 课题负责人.

4.     福建省闽江学者资助. 后基因组时代抗生素的研发. 2015/08-2018/08. ¥ 2,000,000. 课题负责人.

部分文章列表：

1.     Xiaozhao Wang, Zixin Deng, Jiangtao Gao*. Exploring the antibiotic potential of cultured ‘unculturable’ bacteria. Trends in Microbiology. 2024, 32(2):124-127.

2.     Xianming Tang, Lijuan Liao, Yi Lou, Zixin Deng and Jiangtao Gao*. Ethics and engagement: steering China’s synbio future. Trends in Biotechnology. In press.

3.     Yi Lou, Xianming Tang, Lijuan Liao, Zixin Deng and Jiangtao Gao*. Biosafety and biosecurity: treading China’s synbio tightrope. Trends in Biotechnology. In press.

4.     Lijuan Liao, Yi Lou, Xianming Tang, Zixin Deng and Jiangtao Gao*. Intellectual property and funding: fueling Chinese synbio. Trends in Biotechnology. 2024, 42(3):258-260.

5.     Jinhuan Li, Li Li, Jiangtao Gao*. Redefining the Glyphosate Sector: Harmonizing Inventiveness and Sustainable Practices for a Better World. Journal of Agricultural and Food Chemistry. 71, 14393−14395.

6.     Yuqing Li, Yeying Ma, Yinzheng Xia, Tao Zhang, Shuaishuai Sun, Jiangtao Gao,* Hongwei Yao*and Huan Wang *. Discovery and biosynthesis of tricyclic ribosomal peptides containing an unprecedented histidine-to-butyrine crosslink. Nature Communications. 2023, 14(1), 2944.

7.     Liu, Jie, Xiang Guo, Xingchen Guo, Boyuan Zhong, Tao Wang, Dong Liu, Hongwei Jin, Jinwei Ren, Zihe Liu, Jiangtao Gao, Shu-Ming Li, Aili Fan*, and Wenhan Lin*`. Concise Biosynthesis of Tropone-Containing Spiromaterpenes by a Sesquiterpene Cyclase and a Multifunctional P450 from a Deep-Sea-Derived Spiromastix sp. Fungus. Journal of Natural Products. 2022, 85, 2723-2730.

8.     Chu, Leixia, Jinduo Cheng, Chengzeng Zhou, Tianlu Mo, Xinjian Ji, Taoting Zhu, Jie Chen, Suze Ma, Jiangtao Gao*, and Qi Zhang*. Hijacking a Linaridin Biosynthetic Intermediate for Lanthipeptide Production. 2022, 17, 3198-3206. ACS Chemical Biology. (IF=4, Corresponding author).

9.     Leixia Chu, Xiaoxia Luo, Taoting Zhu, Yingying Cao, Lili Zhang, Zixin Deng & Jiangtao Gao*. Harnessing phosphonate antibiotics argolaphos biosynthesis enables a synthetic biology-based green synthesis of glyphosate. 2022. 13, 1736. Nature Communications.

10.  Sa Xiao, Zixin Deng, Jiangtao Gao*. CRISPR/Cas-based strategy for unearthing hidden chemical space from microbial genomes. 2021. 3, 997-1001.Trends in Chemistry.

11.  Xianming Tang, Linsong Shen, Shangshu Liu, Jiangtao Gao*. Effective removal of the herbicide glyphosate by the kelp Saccharina japonica female gametophytes from saline waters and its mechanism elucidation. 2021. 274, 129826. Chemosphere.

12.  Leixia Chu, Jinping Huang, Muhammad Mustafaa, Zixin Deng and Jiangtao Gao*. Genome mining as a biotechnological tool for the discovery of novel marine natural products. 2020. 40, 571-589. Critical Reviews in Biotechnology.

13.  Chengzeng Zhou, Xiaoxia Luo, Nengyi Chen, Lili Zhang,* and Jiangtao Gao*. C−P Natural Products as Next-Generation Herbicides: Chemistry and Biology of Glufosinate. 2020, 68, 3344−3353.  Journal of Agricultural and Food Chemistry

14.  Yingying Cao, Qingyao Peng,  Shanni Li,  Zixin Deng, Jiangtao Gao*. The Intriguing Biology and Chemistry of Fosfomycin: The Only Marketed Phosphonate Antibiotic. 2019. RSC Advances . 9, 42204 – 42218

15.  Yun Zhang, Yingdi Zhang, Li Li,* Xianming Tang,* Jiangtao Gao*, Homogenization significantly enhances growth of macroalga Saccharina japonica female gametophytes. 2019，43, 101640.Algal Research. (IF=5.1, Corresponding author).

16.  Lijuan Liao^†, Xiaolei Zhang^†, Yi Lou, Chengzeng Zhou, Qianqian Yuan and Jiangtao Gao*. Discovery of Three New Phytotoxins from the Fungus Aspergillus nidulans by Pathway Inactivation. 2019. Molecules.  24(3), 515. (IF=4.6, Corresponding author)

17.  Chuchu Guo, Dhanaraju Mandalapu, Xinjjian Ji, Jiangtao Gao*, and Qi Zhang*. Chemistry and Biology of Teixobactin. 2018. Chemistry-A European Journal. 24: 5406-5422.

18.  Haocheng Qianzhu, Wenjuan Ji, Xinjian Ji, Leixia Chu, Chuchu Guo, Wei Lu, Wei Ding, Jiangtao Gao* and    Qi Zhang*. Reactivity of the nitrogen-centered tryptophanyl radical in the catalysis by the radical SAM enzyme NosL. 2017. Chemical Communications. 53, 344-347.

19.  Kou-San Ju, Jiangtao Gao, James R. Doroghazi, Kwo-Kwang A. Wang, Christopher J. Thibodeaux, Steven Li, Emily Metzger, John Fudala, Joleen Su, Jun Kai Zhang, Jaeheon Lee, Joel P. Cioni, Bradley S. Evans, Ryuichi Hirota, David P. Labed, Wilfred A. van der Donka, and William W. Metcalf. Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes.  2015. Proceedings of the National Academy of Sciences of the Unites States of Amercia.112(39):12175-80.

20.  Jiangtao Gao, Kou-San Ju, Xiaomin Yu, Juan E. Velásquez, Subha Mukherjee, Jaeheon Lee, Changming Zhao, Bradley S. Evans, James R. Doroghazi, William W. Metcalf, and Wilfred A. van der Donk. Use of a Phosphonate Methyltransferase in the Identification of the Fosfazinomycin Biosynthetic Gene Cluster. 2014. Angewandte Chemie International Edition. 126, 1358-1361.

21.  Jiangtao Gao, Mohamed M. Radwan, Francisco León, Olivia Reed Dale, Afeef S. Husni, Yunshan Wu, Shari Lupien, Xiaoning Wang, Susan P. Manly, Robert A. Hill,Frank M. Dugan, Horace G. Cutler,and Stephen J. Cutler. Neocosmospora sp.-Derived Resorcylic Acid Lactones with in Vitro Binding Affinity for Human Opioid and Cannabinoid Receptors. Journal of Natural Products. 2013.76, 824-828.

22.  William W. Metcalf, Benjamin M. Griffin, Robert M. Cicchillo, Jiangtao Gao, Sarath Chandra Janga, Heather A. Cooke,  Benjamin T. Circello, Bradley S. Evans,Willm Martens-Habbena, David A. Stahl, and Wilfred A. van der Donk. Synthesis of methylphosphonic acid by marine microbes: a source for methane in the aerobic ocean. Science. 2012. 337,1104-1107.

23.  Jiangtao Gao and Mark T. Hamann. Chemistry and biology of kahalalides. Chemical Reviews.2011. 111, 3208-3215.

24.  Jiangtao Gao, Mohamed M. Radwan, Francisco Leόn, Olivia Reed Dale, Corey Anthony Gemelli, Susan Pinckney Manley, Shari Lupien,Xiaoning Wang, Robert A. Hill, Frank M. Dugan, Horace G. Cutler and  Stephen J. Cutler. Benzyl Derivatives with in Vitro Binding Affinity for Human Opioid Receptors and Cannabinoid Receptors from the Fungus Eurotium repens. Journal of Natural Products. 2011. 74, 1636-1639.

25.  Jiangtao Gao, Mohamed M. Radwan, Francisco Leόn, Shari Lupien, Melissa R. Jacob, Babu L. Tekwani,Shabana I. Khan, Xiaoning Wang, Robert A. Hill, Frank M. Dugan, Horace G. Cutler and  Stephen J. Cutler. Antimicrobial and Antiprotozal Activity of Benzyl Derivatives from the Fungus Eurotium repens. Medicinal Chemistry Research. 2012. 21:3080-3086.

26.  Jiangtao Gao, Catherina Caballero-George, Bin Wang, Karumanchi V. Rao, Abbas Gholipour Shilabin and Mark T. Hamann.5-OHKF and NorKA, Depsipeptides from a Hawaiian Collection of Bryopsispennata: Binding Properties for NorKA to the Human Neuropeptide Y Y₁ Receptor.Journal of Natural Products. 2009. 72, 2172-2176.

27.  Jiangtao Gao, Song Qin and Yicheng Zhang. Rapid optimization of process conditions for cultivation of transgenic Laminaria japonica gametophyte cells in a stirred-bank bioreactor. Chemical Engineering Journal. 2006. 112, 11-14. (IF=15.1)

28.  Jiangtao Gao, Yicheng Zhang, Honghua Wang and Song Qin. Suspension culture of gametophytes of transgenic kelp in a photobioreactor. Biotechnology Letters. 2005. 27, 1025-1028.

29.  Jiangtao Gao, Yicheng Zhang, Wei Zhang, Shaojie Wu, Song Qin, Wei Zhang and Xingju Yu. Optimal light regime for the cultivation of transgenic Laminaria japonica gametophytes in a bubble-column bioreactor. Biotechnology Letters. 2005. 27, 1417-1419.

专利  (PROVISIONAL AND ISSUED)

1. William Metcalf, Kou-san Ju, Jiangtao Gao, James Doroghazi, Wilfred van der Donk. Phosphonic acid compounds and screening method. U.S.Pat. Appl. 2015/041344. Jul. 21. 2015.  WIPO Pat. Appl.  WO/2016/014539. Jan. 16, 2017.